3-phenoxy-.ALPHA.-cyano-benzyl esters, the most potent synthetic pyrethroids.
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چکیده
منابع مشابه
(E)-N-Benzyl-2-cyano-3-phenylacrylamide
In the title compound, C(17)H(14)N(2)O, the N-benzyl-formamide and phenyl groups are located on the opposite sides of the C=C bond, showing an E configuration; the terminal phenyl rings are twisted to each other at a dihedral angle of 63.61 (7)°. Inter-molecular classical N-H⋯N and weak C-H⋯O hydrogen bonds occur in the crystal structure.
متن کاملSynthetic Pyrethroids: Toxicity and Metabolism
Synthetic Pyrethroids are synthetic analogs of naturally occurring pyrethrins, found in extract from Chrysanthemum flowers. They were launched as a replacement of highly toxic class of pesticides like DDT and Organophosphates in 1980s. Major success of pyrethroids lies in the low toxicity of them towards mammals as well as humans and due to which they have wide range of applications right from ...
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A novel approach is reported for the development of fluorogenic esterase reporters using alpha-cyano-containing esters as substrates. After ester hydrolysis, the released alcohol, a cyanohydrin, rapidly eliminates HCN to yield the corresponding aldehyde resulting in strong fluorescence. The pi conjugation of the resulting aldehyde also greatly enhances UV absorption and red shifts fluorescence ...
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Synthetic pyrethroidal compounds undergo biodegradation in mammals both oxidatively and hydrolytically, and depending on the type of compound, either of the pathways may predominate. Thus, (+) - or (+/-) -trans isomers of the chrysanthemumate ester of primary alcohols such as fenothrin, furamethrin, proparthrin, resmethrin, and tetramethrin (and possibly permethrin, too) are metabolized mainly ...
متن کامل(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.
Highly potent and selective CYP2C19 inhibitors are not currently available. In the present study, N-3-benzyl derivatives of nirvanol and phenobarbital were synthesized, their respective (+)- and (-)-enantiomers resolved chromatographically, and inhibitor potencies determined for these compounds toward CYP2C19 and other human liver cytochromes P450 (P450s). (-)-N-3-Benzyl-phenobarbital and (+)-N...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1976
ISSN: 0002-1369,1881-1280
DOI: 10.1271/bbb1961.40.247